A serious multiple-vehicle crash has been reported between the Frankfort/Vrede Interchange and Wilge Plaza in the Free State.
All lanes on the N3 Toll Route, both north and southbound in the vicinity are closed to traffic.
Traffic is currently being stacked at the scene, while emergency services are attending to the numerous crash casualties.
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Motorists have been warned to expect extensive traffic disruptions in the area and to reduce speed while approaching the area with caution.