At least two people were killed on Wednesday in a shooting on a street in the German city of Halle. 

Police said the culprits were on the run.

"Early indications show that two people were killed in Halle. Several shots were fired. The suspected perpetrators fled in a car," said police on Twitter.

They urged residents in the area to stay indoors.

Rail company Deutsche Bahn said the central train station has been closed while the area is under lock down.  

According to German newspaper Bild, the shooting took place in front of a synagogue in the Paulus district, and a hand grenade was also flung into a Jewish cemetery.

Police could not be reached immediately for confirmation.