Johannesburg mayor Mpho Phalatse will be meeting with technical experts following increased numbers of Covid-19 in the province and the identification of the Omicron variant.
In a statement, Phalatse said she was concerned about the new variant and would be consulting with experts with a "view of understanding the variant to guide the City's response to the variant".
"At this stage, there is not a lot of information on this new variant, as scientists continue to research it," said Phalatse.
"The City is continuing with mass vaccination of residents and aims to reach more people as the vaccination rollout remains critical to curbing the impact of the fourth wave. The vaccination programme is a priority in the fight to minimise the spread of Covid-19 infection, as it has been proven that vaccinations decrease the risk of death for those who are immunised."
The fourth wave was likely to peak around mid-December. However, more data modelling would be available in the coming weeks, said Phalatse.
As of Friday, the province had recorded 2 173 new Covid-19 infections - 77% of all new cases in the country.
In a statement on Friday, the Gauteng health department said the number of cases this week was four times higher than in previous weeks, "pointing to an imminent fourth wave".
The City of Johannesburg urged residents to continue wearing a mask in public, sanitise hands and to practice social distancing.
