Two men, believed to be 30 years of age, have died and three others from the same vehicle left injured.
This is after they rolled from the M70 in the Taylors Halt area outside Pietermaritzburg this morning.
The ER24 spokesman Ross Campbell said paramedics arrived at 9:26 am to find the light motor vehicle some distance off the road, it having rolled across a stream.
He said the occupants had been ejected.
"The two males unfortunately showed no signs of life and were declared dead on arrival by ER24. Two other adult males, one critical, the other serious, were treated with Advanced Life Support interventions and transported by another service to Greys Hospital," said Campbell.
Campbell said an 18-year-old female who had suffered moderate injuries was treated and transported by us to Edenvale hospital for further care.
"The South African Police Service and Traffic Department were on the scene for further investigation," he said.